The Nano’s has perfect qualities to equilibrate foremost factors which decide biocatalysts productivity, including particular surface territory, mass exchange protection and successful compound stacking. This audit exhibits the present situation and systems in compound immobilization. A few techniques are utilized which are proficient to join proteins/chemicals with nanoparticles. Immobilization process is to upgrade the operational execution of a catalyst for mechanical applications. So far various lattices have been depicted in the writing to enhance the execution of the immobilized proteins. With the coming of nanotechnology, the nanomaterial due to their one of a kind physico - substance properties constitute novel and fascinating frameworks for compound immobilization.